The M1/M2 macrophage paradigm plays a key role in tumor progression. M1 macrophages
are historically regarded as anti-tumor, while M2-polarized macrophages, commonly …

Single-cell RNA sequencing (scRNA-seq), a technology that analyzes transcriptomes of
complex tissues at single-cell levels, can identify differential gene expression and epigenetic …

Metastasis is the primary cause of cancer morbidity and mortality. The process involves a
complex interplay between intrinsic tumor cell properties as well as interactions between …

Metastasis involves the spread of cancer cells from the primary tumor to surrounding tissues
and to distant organs and is the primary cause of cancer morbidity and mortality. In order to …

Cancer arises in the context of an in vivo tumor microenvironment. This microenvironment is
both a cause and consequence of tumorigenesis. Tumor and host cells co-evolve …

Inflammation is now acknowledged as an hallmark of cancer. Cancer-associated fibroblasts
(CAFs) force a malignant cross talk with cancer cells, culminating in their epithelial …

TAM and other myeloid-derived tumor infiltrating cells are reviewed as pivotal players in the
tumor microenvironment; implications to anti-cancer therapy are described. The …

Background & Aims The roles of alternatively activated (M2) macrophages on pro-tumour
phenotypes have been well documented in many cancers except hepatocellular carcinoma …

Cancer cells that leave the primary tumor can seed metastases in distant organs, and it is
thought that this is a unidirectional process. Here we show that circulating tumor cells …

Metastasis is a multistage process that requires cancer cells to escape from the primary
tumour, survive in the circulation, seed at distant sites and grow. Each of these processes …