ABSTRACT A major advantage of DNA vaccination is the ability to induce both humoral and
cellular immune responses. DNA vaccines are currently used in veterinary medicine, but …

This review provides a detailed look at the attributes and immunologic mechanisms of
plasmid DNA vaccines and their utility as laboratory tools as well as potential human …

Our goal is to develop a vaccine that sustainably prevents Plasmodium falciparum (Pf)
malaria in≥ 80% of recipients. Pf sporozoites (PfSPZ) administered by mosquito bites are …

Successful vaccines contain not only protective antigen (s) but also an adjuvant component
that triggers innate immune activation and is necessary for their optimal immunogenicity,. In …

Abstract Development and Phase 3 testing of the most advanced malaria vaccine, RTS,
S/AS01, indicates that malaria vaccine R&D is moving into a new phase. Field trials of …

Liu MA (Strasbourg, France and Karolinska Institute, Stockholm, Sweden). DNA vaccines: a
review (Review). J Intern Med 2003; 253: 402–410. The DNA vaccines are simple rings of …

In animals, effective immune responses against malignancies and against several infectious
pathogens, including malaria, are mediated by T cells. Here we show that a heterologous …

The innate immune system responds to unique molecular signatures that are widely
conserved among microbes but that are not normally present in host cells. Compounds that …

Nasal delivery offers many benefits over traditional approaches to vaccine administration.
These include ease of administration without needles that reduces issues associated with …

Malaria causes much physical and economic hardship in tropical regions, particularly in
communities where medical care is rudimentary. Should a vaccine be developed, it is the …