Purpose—Much has transpired since the last scientific statement on pediatric stroke was
published 10 years ago. Although stroke has long been recognized as an adult health …

Background: Central nervous system (CNS) complications are among the most common,
devastating sequelae of sickle cell disease (SCD) occurring throughout the lifespan …

Sickle-cell disease is one of the most common severe monogenic disorders in the world.
Haemoglobin polymerisation, leading to erythrocyte rigidity and vaso-occlusion, is central to …

The sickle hemoglobin is an abnormal hemoglobin due to point mutation (GAG→ GTG) in
exon 1 of the β globin gene resulting in the substitution of glutamic acid by valine at position …

Abstract Purpose of Review Sickle cell anemia is a multiorgan disease with acute and
chronic complications. Involvement of the central nervous system (CNS) is associated with …

Moyamoya disease (MMD) and moyamoya syndrome (MMS) are progressive vascular
pathologies unique to the cerebrovasculature that are important causes of stroke in both …

Moyamoya is a progressive arteriopathy of unknown origin affecting the branches of the
internal carotid artery (ICA). The arteriopathy can present as an isolated medical condition …

Sickle cell disease (SCD) is caused by a mutation in both beta globin genes, resulting in
chronic hemolysis and multiorgan disease that ultimately leads to premature death …

Stroke is a frequent and severe complication in adults with sickle cell disease. Ischemic
stroke often causes physical and cognitive disability, while hemorrhagic stroke has a high …

OBJECTIVE The optimal revascularization for pediatric moyamoya for reducing the
incidence of future stroke events remains to be determined. METHODS The authors …