Phenomena such as placebo analgesia or pain relief through distraction highlight the
powerful influence cognitive processes and learning mechanisms have on the way we …

The mammalian nervous system encodes many different forms of pain, from those that arise
as a result of short-term low-grade interactions with noxious thermal, chemical, or …

Arachidonic acid-derived prostaglandins not only contribute to the development of
inflammation as intercellular pro-inflammatory mediators, but also promote the excitability of …

Electrical activity in neurons requires a seamless functional coupling between
plasmalemmal ion channels and ion transporters. Although ion channels have been studied …

Sensory neurons are distinguished by distinct signaling networks and receptive
characteristics. Thus, sensory neuron types can be defined by linking transcriptome-based …

TMEM16 proteins, also known as anoctamins, are involved in a variety of functions that
include ion transport, phospholipid scrambling, and regulation of other membrane proteins …

Our ability to perceive temperature is crucial: it enables us to swiftly react to noxiously cold or
hot objects and helps us to maintain a constant body temperature. Sensory nerve endings …

The transmission and processing of pain signals relies critically on the activities of ion
channels that are expressed in afferent pain fibers. This includes voltage-gated channels, as …

Thermally activated ion channels are known to detect the entire thermal range from extreme
heat (TRPV2), painful heat (TRPV1, TRPM3 and ANO1), non-painful warmth (TRPV3 and …

Humans detect skin temperature changes that are perceived as warm or cool. Like humans,
mice report forepaw skin warming with perceptual thresholds of less than 1° C and do not …