Type 1 diabetes mellitus

A Katsarou, S Gudbjörnsdottir, A Rawshani… - Nature reviews Disease …, 2017 - nature.com
Type 1 diabetes mellitus (T1DM), also known as autoimmune diabetes, is a chronic disease
characterized by insulin deficiency due to pancreatic β-cell loss and leads to …

Standardizing T-cell biomarkers in type 1 diabetes: challenges and recent advances

S Ahmed, K Cerosaletti, E James, SA Long… - Diabetes, 2019 - Am Diabetes Assoc
Type 1 diabetes (T1D) results from the progressive destruction of pancreatic β-cells in a
process mediated primarily by T lymphocytes. The T1D research community has made …

SCT for severe autoimmune diseases: consensus guidelines of the European Society for Blood and Marrow Transplantation for immune monitoring and biobanking

T Alexander, A Bondanza, PA Muraro… - Bone marrow …, 2015 - nature.com
Over the past 15 years, SCT has emerged as a promising treatment option for patients with
severe autoimmune diseases (ADs). Mechanistic studies recently provided the proof-of …

Vaccine against autoimmune disease: antigen-specific immunotherapy

RP Anderson, B Jabri - Current opinion in immunology, 2013 - Elsevier
Recent interest in testing whether the success of antigen-specific immunotherapy (ASIT) for
autoimmune diseases in mice can be translated to humans has highlighted the need for …

Past, present and future of latent autoimmune diabetes in adults

B Liu, Y Xiang, Z Liu, Z Zhou - Diabetes/metabolism research …, 2020 - Wiley Online Library
Latent autoimmune diabetes in adults (LADA) is the most common form of autoimmune
diabetes diagnosed in adults. Similar to type 1 diabetes, the prevalence of LADA is impacted …

Guidelines for standardizing T‐cell cytometry assays to link biomarkers, mechanisms, and disease outcomes in type 1 diabetes

JHM Yang, KA Ward‐Hartstonge… - European journal of …, 2022 - Wiley Online Library
Cytometric immunophenotyping is a powerful tool to discover and implement T‐cell
biomarkers of type 1 diabetes (T1D) progression and response to clinical therapy. Although …

Identification of unique antigenic determinants in the amino terminus of IA-2 (ICA512) in childhood and adult autoimmune diabetes: new biomarker development

M Acevedo-Calado, EA James, MP Morran… - Diabetes …, 2017 - Am Diabetes Assoc
OBJECTIVE The characterization of diverse subtypes of diabetes is a dynamic field of
clinical research and an active area of discussion. The objective of this study was to identify …

Dendritic cells guide islet autoimmunity through a restricted and uniquely processed peptidome presented by high-risk HLA-DR

M Van Lummel, PA Van Veelen, AH De Ru… - The Journal of …, 2016 - journals.aai.org
Identifying T cell epitopes of islet autoantigens is important for understanding type 1
diabetes (T1D) immunopathogenesis and to design immune monitoring and intervention …

Biomarkers and immune-modulating therapies for type 2 diabetes

B Brooks-Worrell, R Narla, JP Palmer - Trends in immunology, 2012 - cell.com
Recent advances in understanding the etiology of obesity, metabolic syndrome, and type 2
diabetes (T2D) have established involvement of the immune system. These developments …

Understanding Islet Autoantibodies in Prediction of Type 1 Diabetes

X Jia, L Yu - Journal of the Endocrine Society, 2024 - academic.oup.com
As screening studies and preventive interventions for type 1 diabetes (T1D) advance rapidly,
the utility of islet autoantibodies (IAbs) in T1D prediction comes with challenges for early and …