Small-cell lung cancer (SCLC) encounters up 15% of all lung cancers, and is characterized
by a high rate of proliferation, a tendency for early metastasis and generally poor prognosis …

Recent studies have demonstrated the potential of natural killer (NK) cells in immunotherapy
to treat multiple types of cancer. NK cells are innate lymphoid cells that play essential roles …

Simple Summary Innate immune natural killer (NK) cells are capable of killing metastatic
cancer cells without activation by antigen-presenting cells beforehand. The cytotoxic effects …

Tumors escape immune surveillance by inducing various immunosuppressive pathways,
including the activation of inhibitory receptors on tumor-infiltrating T cells. While monoclonal …

Abstract Poliovirus receptor (PVR, CD155) has recently been gaining scientific interest as a
therapeutic target in the field of tumor immunology due to its prominent endogenous and …

Metastasis accounts for 90% of cancer-related deaths and, currently, there are no effective
clinical therapies to block the metastatic cascade. A need to develop novel therapies …

CD155 is an adhesion molecule belonging to the Nectin/Nectin-like family often
overexpressed on tumor cells and involved in many different processes such as cell …

Metastasis represents the leading cause of cancer-related death mainly owing to the limited
efficacy of current anticancer therapies on advanced malignancies. Although …

Cancer immunotherapy has been a great breakthrough, with immune checkpoint inhibitors
leading the way. Despite the clinical effectiveness of certain immune checkpoint inhibitors …

Antibody-based therapeutics targeting the inhibitory receptors PD-1, PD-L1, or CTLA-4 have
shown remarkable clinical progress on several cancers. However, most patients do not …