Vaccines based on historical virus isolates provide limited protection from continuously
evolving RNA viruses, such as influenza viruses or coronaviruses, which occasionally spill …

The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) had
become a global concern because of its unexpectedly high pathogenicity and …

Emerging SARS-CoV-2 variants of concern (VOCs) harboring multiple mutations in the spike
protein raise concerns on effectiveness of current vaccines that rely on the ancestral spike …

Because of the rapid mutation and high airborne transmission of SARS‐CoV‐2, a universal
vaccine preventing the infection in the upper respiratory tract is particularly urgent. Here, a …

With the emergence and rapid spread of new pandemic variants, especially variants of
concern (VOCs), the development of next-generation vaccines with broad-spectrum …

SARS-CoV-2 variants have emerged with elevated transmission and a higher risk of
infection for vaccinated individuals. We demonstrate that a recombinant prefusion-stabilized …

The development of a vaccine specific to severe acute respiratory syndrome coronavirus 2
Omicron has been hampered due to its low immunogenicity. Here, using reverse …

Recombinant protein-based vaccines are a valid and safer alternative to traditional vaccines
based on live-attenuated or killed pathogens. However, the immune response of subunit …

As the global COVID-19 pandemic continues and new SARS-CoV-2 variants of concern
emerge, vaccines remain an important tool for preventing the pandemic. The inactivated or …

Objectives To identify the SARS-CoV-2 variants Delta and Omicron during the fourth wave of
the COVID-19 pandemic in Mexico using samples taken from 19 locations in 18 out of the 32 …