Natural product drug discovery in the artificial intelligence era
FI Saldívar-González, VD Aldas-Bulos… - Chemical …, 2022 - pubs.rsc.org
Natural products (NPs) are primarily recognized as privileged structures to interact with
protein drug targets. Their unique characteristics and structural diversity continue to marvel …
protein drug targets. Their unique characteristics and structural diversity continue to marvel …
Advanced methods for natural products discovery: bioactivity screening, dereplication, metabolomics profiling, genomic sequencing, databases and informatic tools …
Natural Products (NP) are essential for the discovery of novel drugs and products for
numerous biotechnological applications. The NP discovery process is expensive and time …
numerous biotechnological applications. The NP discovery process is expensive and time …
Natural products as a source for novel antibiotics
MG Moloney - Trends in pharmacological sciences, 2016 - cell.com
Natural products have historically been of crucial importance in the identification and
development of antibacterial agents. Interest in these systems has waned in recent years …
development of antibacterial agents. Interest in these systems has waned in recent years …
Dereplication: racing to speed up the natural products discovery process
SP Gaudêncio, F Pereira - Natural product reports, 2015 - pubs.rsc.org
Covering: 1993–2014 (July) To alleviate the dereplication holdup, which is a major
bottleneck in natural products discovery, scientists have been conducting their research …
bottleneck in natural products discovery, scientists have been conducting their research …
Machine learning-enabled genome mining and bioactivity prediction of natural products
Natural products (NPs) produced by microorganisms and plants are a major source of drugs,
herbicides, and fungicides. Thanks to recent advances in DNA sequencing, bioinformatics …
herbicides, and fungicides. Thanks to recent advances in DNA sequencing, bioinformatics …
The essentials of marine biotechnology
Coastal countries have traditionally relied on the existing marine resources (eg, fishing,
food, transport, recreation, and tourism) as well as tried to support new economic endeavors …
food, transport, recreation, and tourism) as well as tried to support new economic endeavors …
Machine learning approaches for elucidating the biological effects of natural products
R Zhang, X Li, X Zhang, H Qin, W Xiao - Natural Product Reports, 2021 - pubs.rsc.org
Covering: 2000 to 2020 Machine learning (ML) is an efficient tool for the prediction of
bioactivity and the study of structure–activity relationships. Over the past decade, an …
bioactivity and the study of structure–activity relationships. Over the past decade, an …
Computational methodologies in the exploration of marine natural product leads
F Pereira, J Aires-de-Sousa - Marine drugs, 2018 - mdpi.com
Computational methodologies are assisting the exploration of marine natural products
(MNPs) to make the discovery of new leads more efficient, to repurpose known MNPs, to …
(MNPs) to make the discovery of new leads more efficient, to repurpose known MNPs, to …
[HTML][HTML] Engineering enzymatic assembly lines to produce new antibiotics
KAJ Bozhüyük, J Micklefield, B Wilkinson - Current opinion in microbiology, 2019 - Elsevier
Highlights•Many clinical antibiotics are natural products produced by thiotemplate-based
assembly line biosynthetic pathways.•Assembly line pathways provide an opportunity for …
assembly line biosynthetic pathways.•Assembly line pathways provide an opportunity for …
Harnessing the properties of natural products
A Boufridi, RJ Quinn - Annual review of pharmacology and …, 2018 - annualreviews.org
Natural products (NPs) have been used as traditional medicines since antiquity. With more
than 1060 estimated compounds with molecular weights less than 500 Da representing …
than 1060 estimated compounds with molecular weights less than 500 Da representing …