Efforts to develop anti-cancer therapies have largely focused on targeting the epithelial
compartment, despite the presence of non-neoplastic stromal components that substantially …

Oestrogens and their receptors contribute broadly to physiology and diseases. In
premenopausal women, endogenous oestrogens protect against cardiovascular, metabolic …

Evidence from physical sciences in oncology increasingly suggests that the interplay
between the biophysical tumor microenvironment and genetic regulation has significant …

Immune escape is central to the persistence of most, if not all, solid tumors and poses a
critical obstacle to successful cancer (immuno) therapy. Cancer-associated fibroblasts …

Research on obesity-and diabetes mellitus (DM)-related carcinogenesis has expanded
exponentially since these two diseases were recognized as important risk factors for …

There is extensive evidence supporting the interplay between metabolism and immune
response, that have evolved in close relationship, sharing regulatory molecules and …

Liver fibrosis, a condition characterized by extensive deposition and cross-linking of
extracellular matrix (ECM) proteins, is idiosyncratic in cases of chronic liver injury. The …

G protein-coupled estrogen receptor 1 (GPER1), is a functional estrogen receptor involved
in estrogen related actions on several systems including processes of the nervous …

Pancreatic ductal adenocarcinoma (PDAC) is a gastrointestinal malignancy with a dismal
clinical outcome. Accumulating evidence suggests that activated pancreatic stellate cells …

Estrogens play important roles in the development and progression of multiple tumor types.
Accumulating evidence points to the significance of estrogen action not only in tumors of …