hydroxyanthranilate 3, 4-dioxygenase (HAAO) is an intermediate enzyme in the conversion
from tryptophan (TRP) to nicotinamide adenine dinucleotide (NAD+) via the kynurenine …

Aging is a near ubiquitous phenomenon prevalent across evolutionary lineages from single-
celled organisms to humans. Natural aging is characterized by a progressive deterioration in …

Cancer is the second-leading cause of death in the United States and in Europe. Age is the
single highest risk factor for developing cancer, and more than half of cancer diagnoses …

Aging is experienced by most eukaryotic organisms and age is the primary risk factor for
many of the most common causes of death in humans. Age-related diseases not only …

Aging is a conserved phenomenon that affects many eukaryotic systems. Aging can be
defined as the gradual, chronic loss of function in many biological processes that ultimately …

The kynurenine pathway is the major metabolic route for tryptophan and has been of
increasing interest to many fields of clinical science, including as a potential therapeutic …