The interactions of clinically established anticancer Pt-based drugs with proteins play crucial
roles in Pt cellular uptake and biodistribution, as well as in determining side effects and …

Ruthenium compounds have unique physicochemical properties that can be efficiently
exploited in medicinal chemistry. These molecules can act using both DNA or enzymes as …

Combination therapy targeting both tumor growth and vascularization is considered to be a
cornerstone for colorectal carcinomas (CRC) treatment. However, the major obstacles of …

The reaction between cisplatin and human serum albumin (HSA) was investigated by X-ray
crystallography and crystal structures of the cisplatin/HSA adduct were eventually solved for …

The development of bifunctional platinum complexes with the ability to interact with DNA via
different binding modes is of interest in anticancer metallodrug research. Therefore, we …

Protein metalation is a process that determines the formation of adducts upon reaction of
metal compounds with proteins. Protein metalation plays a crucial role in different fields …

Platinum-complexes represent some of the most successful groups of clinically used
anticancer drugs. Their mechanism of action relies on the formation of stable DNA adducts …

Cisplatin (cisPt), Pt (NH3) 2Cl2, is a cancer drug believed to kill cells via DNA binding and
damage. Recent work has implied that the cellular copper (Cu) transport machinery may be …

Arsenoplatins are adducts of two chemically important anticancer drugs, cisplatin and
arsenic trioxide, that have a Pt (II) bond to an As (III) hydroxide center. Screens of the NCI-60 …

In this study, the binding to lysozyme (Lyz) of four important VIV compounds with antidiabetic
and/or anticancer activity,[VIVO (pic) 2 (H2O)],[VIVO (ma) 2],[VIVO (dhp) 2], and [VIVO (acac) …