The ability to adapt to altered availability of free water is a fundamental property of living
cells. The principles underlying osmoadaptation are well conserved. The yeast …

Convincing concepts of redox control of gene transcription have been worked out for
prokaryotes and lower eukaryotes, whereas the knowledge on complex mammalian systems …

Since their discovery as a substrate for ribonucleotide reductase (RNR), the role of
thioredoxin (Trx) and glutaredoxin (Grx) has been largely extended through their regulatory …

In yeast, as in higher eukaryotes, reactive oxygen species are produced as normal by-
products of cellular metabolism. Under physiological conditions, the cell defence …

Summary Eukaryotic 2-Cys peroxiredoxins (Prx) are abundant antioxidant enzymes whose
thioredoxin peroxidase activity plays an important role in protecting against oxidative stress …

Activation of redox cascades through hydrogen peroxide-mediated reversible cysteine
oxidation is a major mechanism for intracellular signaling. Understanding why some …

An increasing body of evidence indicates that oxidative stress and damage play a role in the
pathogenesis of a number of diseases associated with neurodegeneration, including Down …

The beginnings of redox biology are recalled with special emphasis on formation,
metabolism and function of reactive oxygen and nitrogen species in mammalian systems …

Yap1p, a crucial transcription factor in the oxidative stress response of Saccharomyces
cerevisiae, is transported in and out of the nucleus under nonstress conditions. The nuclear …

The eukaryotic cytoplasm has long been regarded as a cellular compartment in which the
reduced state of protein cysteines is largely favored. Under normal conditions, the cytosolic …