Hippo–YAP/TAZ signalling in organ regeneration and regenerative medicine
The Hippo pathway and its downstream effectors, the transcriptional co-activators Yes-
associated protein (YAP) and transcriptional co-activator with PDZ-binding motif (TAZ) …
associated protein (YAP) and transcriptional co-activator with PDZ-binding motif (TAZ) …
[HTML][HTML] Role of YAP/TAZ in cell lineage fate determination and related signaling pathways
BC Heng, X Zhang, D Aubel, Y Bai, X Li… - Frontiers in cell and …, 2020 - frontiersin.org
The penultimate effectors of the Hippo signaling pathways YAP and TAZ, are transcriptional
co-activator proteins that play key roles in many diverse biological processes, ranging from …
co-activator proteins that play key roles in many diverse biological processes, ranging from …
TEAD family transcription factors in development and disease
L Currey, S Thor, M Piper - Development, 2021 - journals.biologists.com
The balance between stem cell potency and lineage specification entails the integration of
both extrinsic and intrinsic cues, which ultimately influence gene expression through the …
both extrinsic and intrinsic cues, which ultimately influence gene expression through the …
Matrix remodeling enhances the differentiation capacity of neural progenitor cells in 3D hydrogels
Neural progenitor cells (NPCs) are a promising cell source to repair damaged nervous
tissue. However, expansion of therapeutically relevant numbers of NPCs and their efficient …
tissue. However, expansion of therapeutically relevant numbers of NPCs and their efficient …
[HTML][HTML] The biophysical property of the limbal niche maintains stemness through YAP
S Bhattacharya, A Mukherjee, S Pisano… - Cell Death & …, 2023 - nature.com
The cell fate decisions of stem cells (SCs) largely depend on signals from their
microenvironment (niche). However, very little is known about how biochemical niche cues …
microenvironment (niche). However, very little is known about how biochemical niche cues …
Recent advances of the Hippo/YAP signaling pathway in brain development and glioma
T Ouyang, W Meng, M Li, T Hong, N Zhang - Cellular and molecular …, 2020 - Springer
The Hippo signaling pathway is highly conserved from Drosophila melanogaster to
mammals and plays a crucial role in organ size control, tissue regeneration, and tumor …
mammals and plays a crucial role in organ size control, tissue regeneration, and tumor …
Neuronal Hippo signaling: From development to diseases
Hippo signaling pathway is a highly conserved and familiar tissue growth regulator, primarily
dealing with cell survival, cell proliferation, and apoptosis. The Yes‐associated protein …
dealing with cell survival, cell proliferation, and apoptosis. The Yes‐associated protein …
[HTML][HTML] The role and regulatory mechanism of hippo signaling components in the neuronal system
J Cheng, S Wang, Y Dong, Z Yuan - Frontiers in immunology, 2020 - frontiersin.org
The Hippo signaling pathway, an evolutionarily conserved protein kinase cascade, plays a
critical role in controlling organ size, cancer development, and tissue regeneration …
critical role in controlling organ size, cancer development, and tissue regeneration …
[HTML][HTML] Tead transcription factors differentially regulate cortical development
Neural stem cells (NSCs) generate neurons of the cerebral cortex with distinct morphologies
and functions. How specific neuron production, differentiation and migration are …
and functions. How specific neuron production, differentiation and migration are …
[HTML][HTML] TEAD transcription factors are required for normal primary myoblast differentiation in vitro and muscle regeneration in vivo
S Joshi, G Davidson, S Le Gras, S Watanabe… - PLoS …, 2017 - journals.plos.org
The TEAD family of transcription factors (TEAD1-4) bind the MCAT element in the regulatory
elements of both growth promoting and myogenic differentiation genes. Defining TEAD …
elements of both growth promoting and myogenic differentiation genes. Defining TEAD …