Cytokines of the transforming growth factor β (TGF-β) family, including TGF-βs, bone
morphogenic proteins (BMPs), activins, and Nodal, play crucial roles in embryonic …

The genetically tractable model organism Caenorhabditis elegans was first used to model
bacterial virulence in vivo a decade ago. Since then, great strides have been made in …

Kidney cells and tissues derived from human pluripotent stem cells (hPSCs) may enable
organ regeneration, disease modeling and drug screening. We report an efficient …

Summary Recapitulating three-dimensional (3D) structures of complex organs, such as the
kidney, from pluripotent stem cells (PSCs) is a major challenge. Here, we define the …

Somatic cell nuclear transfer and transcription-factor-based reprogramming revert adult cells
to an embryonic state, and yield pluripotent stem cells that can generate all tissues. Through …

Progress toward finding a cure for muscle diseases has been slow because of the absence
of relevant cellular models and the lack of a reliable source of muscle progenitors for …

A variety of protocols have been developed that demonstrate the capability to differentiate
human pluripotent stem cells (hPSCs) into kidney structures. Our goal was to develop a high …

Biomechanical forces are emerging as critical regulators of embryogenesis, particularly in
the developing cardiovascular system,. After initiation of the heartbeat in vertebrates, cells …

Transforming growth factor (TGF)-βs and their family members, including bone
morphogenetic proteins (BMPs), Nodal and activins, have been implicated in the …

BMP and Wnt signaling pathways control essential cellular responses through activation of
the transcription factors SMAD (BMP) and TCF (Wnt). Here, we show that regeneration of …