Stress granules (SGs) are phase-separated, membraneless, cytoplasmic ribonucleoprotein
(RNP) assemblies whose primary function is to promote cell survival by condensing …

Chromosomal instability (CIN) is associated with many human diseases, including
neurodevelopmental or neurodegenerative conditions, age-related disorders and cancer …

Germinal centers (GCs) are essential for the establishment of long-lasting antibody
responses. GC B cells rely on post-transcriptional RNA mechanisms to translate activation …

Genome integrity must be tightly preserved to ensure cellular survival and to deter the
genesis of disease. Endogenous and exogenous stressors that impose threats to genomic …

Current models posit that nuclear speckles (NSs) serve as reservoirs of splicing factors and
facilitate posttranscriptional mRNA processing. Here, we discovered that ribotoxic stress …

Genome integrity requires replication to be completed before chromosome segregation. The
DNA-replication checkpoint (DRC) contributes to this coordination by inhibiting CDK1, which …

Fidelity in chromosome duplication and segregation is indispensable for maintaining
genomic stability and the perpetuation of life. Challenges to genome integrity jeopardize cell …

T-cell intracellular antigen 1 (TIA1)-related/like (TIAR/TIAL1) protein is a multifunctional RNA-
binding protein (RBP) involved in regulating many aspects of gene expression …

Ovarian cancer often develops resistance to conventional therapies, hampering their
effectiveness. Here, using ex vivo paired ovarian cancer ascites obtained before and after …

Background and Aim. The senescence of human bone marrow mesenchymal stem cells
(hBMSCs) can be induced by oxidative stress, but the mechanism by which it occurs is not …