Simple Summary Breast cancer is the most common cancer among women. It is estimated
that 2.3 million new cases of BC are diagnosed globally each year. Based on mRNA gene …

TP53, a crucial tumor suppressor gene, is the most commonly mutated gene in human
cancers. Aside from losing its tumor suppressor function, mutant p53 (mutp53) often …

We integrated the genomic sequencing of 1,918 breast cancers, including 1,501 hormone
receptor-positive tumors, with detailed clinical information and treatment outcomes. In 692 …

Purpose: To construct an immune-related gene prognostic index (IRGPI) for head and neck
squamous cell carcinoma (HNSCC) and clarify the molecular and immune characteristics …

Abstract Background The phase III MONALEESA-2 study demonstrated significantly
prolonged progression-free survival (PFS) and a manageable toxicity profile for first-line …

Breast cancer is a complex disease encompassing multiple tumor entities, each
characterized by distinct morphology, behavior and clinical implications. Besides estrogen …

Tumor suppressor p53 plays a central role in tumor suppression. p53 is the most frequently
mutated gene in human cancer, and over half of human cancers contain p53 mutations …

There is now strong evidence that mutation not only abrogates p53 tumor-suppressive
functions, but in some instances can also endow mutant proteins with novel activities. Such …

Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer that lacks
expression of the estrogen receptor (ER), progesterone receptor (PR), and human …

Inactivation of the p53 tumor suppressor is a frequent event in tumorigenesis. In most cases,
the p53 gene is mutated, giving rise to a stable mutant protein whose accumulation is …