There is an increasing prevalence of Vascular Cognitive Impairment (VCI) worldwide, and
several studies have suggested that Chronic Cerebral Hypoperfusion (CCH) plays a critical …

Vascular cognitive impairment (VCI) describes a wide spectrum of cognitive deficits related
to cerebrovascular diseases. Although the loss of blood flow to cortical regions critically …

Microglial activation participates in white matter injury after cerebral hypoperfusion.
However, the underlying mechanism is unclear. Here, we explore whether activated …

The complement system is an essential part of innate immunity, typically conferring
protection via eliminating pathogens and accumulating debris. However, the defensive …

Vascular cognitive impairment (VCI) refers to all forms of cognitive disorder related to
cerebrovascular diseases, including vascular mild cognitive impairment, post-stroke …

Chronic vascular encephalopathy (CVE) is a frequent cause of vascular mild cognitive
impairment and dementia, which significantly worsens the quality of life, especially in the …

Murine chronic cerebral hypoperfusion (CCH) results in white matter (WM) injury and
behavioral deficits. Pericytes influence blood–brain barrier (BBB) integrity and cerebral …

We previously reported that remote limb ischemic conditioning (RLIC; PERconditioning)
during acute stroke confers neuroprotection, possibly due to increased cerebral blood flow …

Background: Exposure to ambient air pollution particulate matter (PM) is associated with
increased risk of dementia and accelerated cognitive loss. Vascular contributions to …

Vascular dementia (VD) is the second leading cause of dementia after Alzheimer's disease
(AD). The decrease of cerebral blood flow (CBF) to different degrees is one of the main …