New and emerging targeted therapies for hidradenitis suppurativa

A Markota Čagalj, B Marinović… - International journal of …, 2022 - mdpi.com
Hidradenitis suppurativa (HS) is a chronic, recurrent, inflammatory skin disease deriving
from the hair follicles. The formation of inflammatory nodules, abscesses, fistulas, and sinus …

Biologics for hidradenitis suppurativa: evolution of the treatment paradigm

CA Maronese, C Moltrasio, G Genovese… - Expert Review of …, 2024 - Taylor & Francis
Introduction Hidradenitis suppurativa (HS) is an autoinflammatory skin disease with a high
unmet need for effective medical management. Clinically, it is characterized by inflammatory …

Skin and gut microbiome in hidradenitis suppurativa: a systematic review

E Lelonek, D Bouazzi, GBE Jemec, JC Szepietowski - Biomedicines, 2023 - mdpi.com
Hidradenitis suppurativa (HS) is a chronic skin disease that significantly impairs the quality
of life of affected individuals. The disease is characterized by persistent purulent lesions in …

Hidradenitis suppurativa: new insights into disease mechanisms and an evolving treatment landscape

JG Krueger, J Frew, GBE Jemec… - British Journal of …, 2024 - academic.oup.com
Hidradenitis suppurativa (HS), also known as acne inversa, is a chronic disabling and
debilitating inflammatory disease with a high unmet medical need. The prevalence of HS …

The use of ultrasound and magnetic resonance imaging in the management of hidradenitis suppurativa: a narrative review

P Mendes-Bastos, A Martorell, V Bettoli… - British Journal of …, 2023 - academic.oup.com
Hidradenitis suppurativa (HS) is a chronic, inflammatory follicular skin disease that
frequently affects the apocrine gland-bearing skin of the axillary, inguinal and anogenital …

Aberrant expression of interleukin-17A in mast cells contributes to the pathogenesis of hidradenitis suppurativa

CB Chu, CC Yang, YY Hsueh, PC Chen… - British Journal of …, 2023 - academic.oup.com
Background Hidradenitis suppurativa (HS) significantly diminishes the quality of life for
patients. Delayed diagnosis represents a significant challenge in effectively managing HS …

The essential role of micrornas in inflammatory and autoimmune skin diseases—a review

K Dopytalska, A Czaplicka, E Szymańska… - International Journal of …, 2023 - mdpi.com
The etiopathogenesis of autoimmune skin diseases is complex and still not fully understood.
The role of epigenetic factors is emphasized in the development of such diseases …

A proof-of-concept open-label clinical trial of spleen tyrosine kinase antagonism using fostamatinib in moderate-to-severe hidradenitis suppurativa

R Jepsen, C Edwards, A Flora, E Kozera… - Journal of the American …, 2023 - Elsevier
Background Hidradenitis suppurativa (HS) is an autoinflammatory disorder of keratinization
with a prominence of B cells and plasma cells. Fostamatinib is a spleen tyrosine kinase …

Obesity and hidradenitis suppurativa: targeting meta-inflammation for therapeutic gain

D Mintoff, R Agius, F Benhadou, A Das… - Clinical and …, 2023 - academic.oup.com
Hidradenitis suppurativa (HS) is a chronic, inflammatory condition of the pilosebaceous unit.
The typical patient with HS is characterized as someone with obesity, who smokes and who …

Brepocitinib, Zimlovisertib, and Ropsacitinib in Hidradenitis Suppurativa

AB Kimball, E Peeva, S Forman, A Moiin… - NEJM …, 2024 - evidence.nejm.org
Background Hidradenitis suppurativa (HS) is a debilitating, inflammatory skin disease with
limited treatment options and partially understood pathophysiology. Using an umbrella trial …