Cholesterol is an essential component for neuronal physiology not only during development
stage but also in the adult life. Cholesterol metabolism in brain is independent from that in …

The vast majority of Alzheimer's disease (AD) cases are late-onset and their development is
probably influenced by both genetic and environmental risk factors. A strong genetic risk …

PICALM is a highly validated genetic risk factor for Alzheimer's disease (AD). We found that
reduced expression of PICALM in AD and murine brain endothelium correlated with amyloid …

According to the neurovascular hypothesis, impairment of low-density lipoprotein receptor–
related protein-1 (LRP1) in brain capillaries of the blood-brain barrier (BBB) contributes to …

Neurotoxic amyloid β peptide (Aβ) accumulates in the brains of individuals with Alzheimer
disease (AD). The APOE4 allele is a major risk factor for sporadic AD and has been …

The main receptors for amyloid-beta peptide (Aβ) transport across the blood-brain barrier
(BBB) from brain to blood and blood to brain are low-density lipoprotein receptor related …

LRP (low-density lipoprotein receptor-related protein) is linked to Alzheimer's disease (AD).
Here, we report amyloid β-peptide Aβ40 binds to immobilized LRP clusters II and IV with …

Accumulation and aggregation of amyloid-β (Aβ) peptides in the brain trigger the
development of progressive neurodegeneration and dementia associated with Alzheimer's …

Clathrin-mediated endocytosis oversees the constitutive packaging of selected membrane
cargoes into transport vesicles that fuse with early endosomes. The process is responsive to …

Amyloid beta (Aβ) homeostasis in the brain is governed by its production and clearance
mechanisms. An imbalance in this homeostasis results in pathological accumulations of …