Cytokine networks are crucial aspects of tumour immunology, particularly for colorectal
cancer (CRC), in which inflammation and antitumour immunity are key determinants of …

Signal transduction activator of transcription (STAT) 3 is a member of the STAT protein family
which transduces intracellular and extracellular signals to the nucleus, controlling the …

The consequences of prostate cancer metastasis remain severe, with huge impact on the
mortality and overall quality of life of affected patients. Despite the convoluted interplay and …

To investigate whether IL‐6 signaling affects the susceptibility of castration‐resistant
prostate cancer (CRPC) cells to cytotoxic action of natural killer (NK) cells, CRPC cell lines …

In prostate cancer (PCa), similar to many other cancers, distant organ metastasis symbolizes
the beginning of the end disease, which eventually leads to cancer death. Many …

Abstract Interleukin (IL)-6 is a pro-inflammatory cytokine that is expressed in prostate tumors
and in the stromal tumor micro-enviroment. It is known to regulate proliferation, apoptosis …

In the era of precision medicine, the identification of new targets is a constant challenge to
improve cancer therapy. Preclinical investigations, epidemiological studies and analyses of …

Ovarian carcinoma is the fifth leading cause of death among women in the United States.
Persistent activation of STAT3 is frequently detected in ovarian carcinoma. STAT3 is …

Signal transducers and activators of transcription 3 (STAT-3) is a transcription factor that
regulates the gene expression of several target genes. These factors are activated by the …

Cytokines are well known mediators of numerous physiological and pathological processes.
They contribute to the regulation of normal hematopoiesis but increasing data suggest that …