The contribution of astrocytes to the neuroinflammatory response in multiple sclerosis and experimental autoimmune encephalomyelitis
R Brambilla - Acta neuropathologica, 2019 - Springer
Neuroinflammation is the coordinated response of the central nervous system (CNS) to
threats to its integrity posed by a variety of conditions, including autoimmunity, pathogens …
threats to its integrity posed by a variety of conditions, including autoimmunity, pathogens …
Magnetic resonance of myelin water: an in vivo marker for myelin
Myelin is critical for healthy brain function. An accurate in vivo measure of myelin content
has important implications for understanding brain plasticity and neurodegenerative …
has important implications for understanding brain plasticity and neurodegenerative …
Pathogenesis of multiple sclerosis: insights from molecular and metabolic imaging
The mechanisms underlying the pathogenesis of multiple sclerosis induce the changes that
underpin relapse-associated and progressive disability. Disease mechanisms can be …
underpin relapse-associated and progressive disability. Disease mechanisms can be …
Quantifying the Metabolic Signature of Multiple Sclerosis by in vivo Proton Magnetic Resonance Spectroscopy: Current Challenges and Future Outlook in the …
Proton magnetic resonance spectroscopy (1H-MRS) offers a growing variety of methods for
querying potential diagnostic biomarkers of multiple sclerosis in living central nervous …
querying potential diagnostic biomarkers of multiple sclerosis in living central nervous …
Extensive brain pathologic alterations detected with 7.0-T MR spectroscopic imaging associated with disability in multiple sclerosis
Background MR spectroscopic imaging (MRSI) allows in vivo assessment of brain
metabolism and is of special interest in multiple sclerosis (MS), where morphologic MRI …
metabolism and is of special interest in multiple sclerosis (MS), where morphologic MRI …
Myelin water imaging to detect demyelination and remyelination and its validation in pathology
C Laule, GRW Moore - Brain Pathology, 2018 - Wiley Online Library
Damage to myelin is a key feature of multiple sclerosis (MS) pathology. Magnetic resonance
imaging (MRI) has revolutionized our ability to detect and monitor MS pathology in vivo …
imaging (MRI) has revolutionized our ability to detect and monitor MS pathology in vivo …
[HTML][HTML] Acting centrally or peripherally: A renewed interest in the central nervous system penetration of disease-modifying drugs in multiple sclerosis
J Correale, MJ Halfon, D Jack, A Rubstein… - Multiple Sclerosis and …, 2021 - Elsevier
With the recent approval of cladribine tablets, siponimod and ozanimod, there has been a
renewed interest into the extent to which these current generation disease-modifying …
renewed interest into the extent to which these current generation disease-modifying …
Deep-learning generated synthetic double inversion recovery images improve multiple sclerosis lesion detection
T Finck, H Li, L Grundl, P Eichinger… - Investigative …, 2020 - journals.lww.com
Objectives The aim of the study was to implement a deep-learning tool to produce synthetic
double inversion recovery (synthDIR) images and compare their diagnostic performance to …
double inversion recovery (synthDIR) images and compare their diagnostic performance to …
Altered in vivo brain GABA and glutamate levels are associated with multiple sclerosis central fatigue
Purpose Fatigue is a common symptom in patients with multiple sclerosis (MS) with
unknown pathophysiology. Dysfunction of the GABAergic/glutamatergic pathways involving …
unknown pathophysiology. Dysfunction of the GABAergic/glutamatergic pathways involving …
Predictive MRI biomarkers in MS—A critical review
Background and Objectives: In this critical review, we explore the potential use of MRI
measurements as prognostic biomarkers in multiple sclerosis (MS) patients, for both …
measurements as prognostic biomarkers in multiple sclerosis (MS) patients, for both …