Porcine circovirus type 2 (PCV2): pathogenesis and interaction with the immune system
XJ Meng - Annu. Rev. Anim. Biosci., 2013 - annualreviews.org
Porcine circovirus type 2 (PCV2) is the primary causative agent of porcine circovirus–
associated disease (PCVAD). The virus preferentially targets the lymphoid tissues, which …
associated disease (PCVAD). The virus preferentially targets the lymphoid tissues, which …
Advances in crosstalk between porcine circoviruses and host
G Niu, S Chen, X Li, L Zhang, L Ren - Viruses, 2022 - mdpi.com
Porcine circoviruses (PCVs), including PCV1 to PCV4, are non-enveloped DNA viruses with
a diameter of about 20 nm, belonging to the genus Circovirus in the family Circoviridae …
a diameter of about 20 nm, belonging to the genus Circovirus in the family Circoviridae …
Current understanding of genomic DNA of porcine circovirus type 2
Q Lv, K Guo, Y Zhang - Virus genes, 2014 - Springer
Abstract Porcine circovirus type 2 (PCV2) is the primary causative agent of porcine circovirus-
associated diseases in swine and is also described as the modulator of host immunity that …
associated diseases in swine and is also described as the modulator of host immunity that …
Interactions of porcine circovirus 2 with its hosts
L Ren, X Chen, H Ouyang - Virus genes, 2016 - Springer
Abstract Porcine circovirus 2 (PCV2) can cause porcine circovirus diseases and porcine
circovirus-associated diseases (PCVD/PCVAD), which are widely presented in swine …
circovirus-associated diseases (PCVD/PCVAD), which are widely presented in swine …
Viral takeover of the host ubiquitin system
JK Gustin, AV Moses, K Früh, JL Douglas - Frontiers in microbiology, 2011 - frontiersin.org
Like the other more well-characterized post-translational modifications (phosphorylation,
methylation, acetylation, acylation, etc.), the attachment of the 76 amino acid ubiquitin (Ub) …
methylation, acetylation, acylation, etc.), the attachment of the 76 amino acid ubiquitin (Ub) …
The role of E3 ligase Pirh2 in disease
A Daks, O Fedorova, S Parfenyev, I Nevzorov… - Cells, 2022 - mdpi.com
The p53-dependent ubiquitin ligase Pirh2 regulates a number of proteins involved in
different cancer-associated processes. Targeting the p53 family proteins, Chk2, p27Kip1 …
different cancer-associated processes. Targeting the p53 family proteins, Chk2, p27Kip1 …
[HTML][HTML] Pirh2 RING-finger E3 ubiquitin ligase: its role in tumorigenesis and cancer therapy
The ubiquitin-dependent proteasome system plays a critical role in many cellular processes
and pathogenesis of various human diseases, including cancer. Although there are a large …
and pathogenesis of various human diseases, including cancer. Although there are a large …
Apoptosis Triggered by ORF3 Proteins of the Circoviridae Family
Y Zhang, X Zhang, A Cheng, M Wang, Z Yin… - Frontiers in Cellular …, 2021 - frontiersin.org
Apoptosis, a form of the programmed cell death, is an indispensable defense mechanism
regulating cellular homeostasis and is triggered by multiple stimuli. Because of the …
regulating cellular homeostasis and is triggered by multiple stimuli. Because of the …
[HTML][HTML] ORF3 of porcine circovirus 2 enhances the in vitro and in vivo spread of the of the virus
AK Karuppannan, J Kwang - Virology, 2011 - Elsevier
The ORF3 protein of the pathogenic porcine circovirus 2 (PCV2) causes apoptosis of the
virus-infected cells. In PCV2-infected piglets, ORF3 induces B and CD4 T lymphocyte …
virus-infected cells. In PCV2-infected piglets, ORF3 induces B and CD4 T lymphocyte …
Porcine circovirus 2 activates the PERK-reactive oxygen species axis to induce p53 phosphorylation with subsequent cell cycle arrest at S phase in favor of its …
Z Deng, R Sun, X Han, Y Zhang, Y Zhou… - Journal of …, 2022 - Am Soc Microbiol
ABSTRACT Porcine circovirus type 2 (PCV2), the causative agent of porcine circovirus-
associated diseases (PCVAD), is known to induce oxidative stress, activate p53 with …
associated diseases (PCVAD), is known to induce oxidative stress, activate p53 with …