Bone fractures and segmental bone defects are a significant source of patient morbidity and
place a staggering economic burden on the healthcare system. The annual cost of treating …

Bone-related diseases are major contributors to morbidity and mortality in elderly people
and the current treatments result in insufficient healing and several complications. One of the …

Administration of exosomes is considered an attractive cell-free approach to skeletal repair
and pathological disease treatment. However, poor yield for the production technique and …

Tuning hydrogel degradation enables effective and successful tissue regeneration by
modulating cellular behaviors and matrix formation. In this work, we develop a novel …

With population aging and increased life expectancy, an increasing number of people are
facing musculoskeletal health problems that necessitate therapeutic intervention at defect …

For effective treatment of infected bone, it is essential to use local drug delivery systems with
the ability to deliver both antibiotics and osteoinductive factors. Herein, a pH-sensitive silk …

Between 5 and 10 percent of fractures do not heal, a condition known as nonunion. In
clinical practice, stable fracture fixation associated with autologous iliac crest bone graft …

Our previous finding revealed that the Wnt10b RNA expression of osteoporotic adipose‐
derived stem cells (OP‐ASCs) with impaired osteogenic capacity was significantly reduced …

Aberrant lineage commitment of mesenchymal stem cells (MSCs) in marrow contributes to
abnormal bone formation due to reduced osteogenic and increased adipogenic potency …

Repairing critical size bone defects (CSBD) is a major clinical challenge and requires
effective intervention by biomaterial scaffolds. Inspired by the fact that the cartilaginous …