Metabolic reprogramming of the intestinal microbiome with functional bile acid changes underlie the development of NAFLD

E Smirnova, MD Muthiah, N Narayan, MS Siddiqui… - Hepatology, 2022 - journals.lww.com
Autoimmune hepatitis (AIH) is a rare disease of unclear etiology characterized by loss of self‐
tolerance that can lead to liver injury, cirrhosis, and acute liver failure. First‐line treatment …

[PDF][PDF] Noninvasive biomarkers for the diagnosis and management of autoimmune hepatitis

C Harrington, S Krishnan, CL Mack, P Cravedi… - …, 2022 - Wiley Online Library
Autoimmune hepatitis (AIH) is a rare disease of unclear etiology characterized by loss of self‐
tolerance that can lead to liver injury, cirrhosis, and acute liver failure. First‐line treatment …

Mucus, commensals, and the immune system

Q Zhao, CL Maynard - Gut microbes, 2022 - Taylor & Francis
The immune system in the large intestine is separated from commensal microbes and
comparatively rare enteric pathogens by a monolayer of diverse epithelial cells overlaid with …

Evaluation of Intestinal Fibrosis with 68Ga-FAPI PET/MR Enterography in Crohn Disease

M Scharitzer, A Macher-Beer, T Mang, LW Unger… - Radiology, 2023 - pubs.rsna.org
Background In Crohn disease, differentiation between active intestinal inflammation and
fibrosis has implications for treatment, but current imaging modalities are not reliably …

Therapeutic targeting of intestinal fibrosis in Crohn's disease

G Santacroce, MV Lenti, A Di Sabatino - Cells, 2022 - mdpi.com
Intestinal fibrosis is one of the most threatening complications of Crohn's disease. It occurs in
more than a third of patients with this condition, is associated with increased morbidity and …

Hypoxia-inducible factor as a bridge between healthy barrier function, wound healing, and fibrosis

CA Steiner, IM Cartwright, CT Taylor… - American Journal of …, 2022 - journals.physiology.org
The healthy mammalian intestine is lined by a single layer of epithelial cells. These cells
provide a selectively permeable barrier to luminal contents and normally do so in an efficient …

Fibrosis in IBD: from pathogenesis to therapeutic targets

F Rieder, PK Mukherjee, WJ Massey, Y Wang… - Gut, 2024 - gut.bmj.com
Background Intestinal fibrosis resulting in stricture formation and obstruction in Crohn's
disease (CD) and increased wall stiffness leading to symptoms in ulcerative colitis (UC) is …

PPAR-gamma orchestrates EMT, AGE, and cellular senescence pathways in colonic epithelium and restrains the progression of IBDs

S Pompili, A Vetuschi, G Latella, A Smakaj… - International Journal of …, 2023 - mdpi.com
Intestinal fibrosis, the most common complication of inflammatory bowel disease (IBD), is
characterized by an uncontrolled deposition of extracellular matrix proteins leading to …

Crohn's disease related strictures in cross‐sectional imaging: More than meets the eye?

J Sleiman, P Chirra, NS Gandhi… - United European …, 2022 - Wiley Online Library
Strictures in Crohn's disease (CD) are a hallmark of long‐standing intestinal damage,
brought about by inflammatory and non‐inflammatory pathways. Understanding the complex …

Ultrasound elastography in the assessment of the intestinal changes in inflammatory bowel disease—systematic review

D Ślósarz, E Poniewierka, K Neubauer… - Journal of Clinical …, 2021 - mdpi.com
Inflammatory bowel disease (IBD) is a chronic condition affecting primarily the
gastrointestinal tract and characterized by growing incidence worldwide. Complex …