The plasticity of cancer cells underlies their capacity to adapt to the selective pressures they
encounter during tumour development. Aberrant reactivation of epithelial–mesenchymal …

Cancer is a complex multistep process involving genetic and epigenetic changes that
eventually result in the activation of oncogenic pathways and/or inactivation of tumor …

The transcription factor nuclear factor kappa B (NF-κB) is constitutively active in both cancer
cells and stromal cells of breast cancer; however, the precise role of activated NF-κB in …

In contrast to the well-recognized replicative and stress-induced premature senescence of
normal somatic cells, mechanisms and clinical implications of senescence of cancer cells …

Embryonic differentiation programs of epithelial–mesenchymal and mesenchymal–epithelial
transition (EMT and MET) represent a mechanistic basis for epithelial cell plasticity …

Senescence induction could be used as an effective treatment for hepatocellular carcinoma
(HCC). However, major senescence inducers (p53 and p16Ink4a) are frequently inactivated …

The therapeutic induction of senescence is a potential means to treat cancer, primarily
acting through the induction of a persistent growth‐arrested state in tumors. However, recent …

The ZEB family of transcription factors regulates key factors during embryonic development
and cell differentiation but their role in cancer biology has only more recently begun to be …

Cellular senescence is recognized as a critical cellular response to prolonged rounds of
replication and environmental stresses. Its defining characteristics are arrested cell-cycle …

The epithelial-mesenchymal transition (EMT) contributes to cancer metastasis. Two ZEB
family members, ZEB1 and ZEB2 (SIP1), inhibit transcription of the E-cadherin gene and …