The human nervous system is a remarkably complex physiological network that is inherently
challenging to study because of obstacles to acquiring primary samples. Animal models …

Neurological disorders have emerged as a predominant healthcare concern in recent years
due to their severe consequences on quality of life and prevalence throughout the world …

Current brain spheroids or organoids derived from human induced pluripotent stem cells
(hiPSCs) still lack a microglia component, the resident immune cells in the brain. The …

Plastics have been part of our ecosystem for about a century and their degradation by
different environmental factors produce secondary microplastics (MPs). To date, the impact …

Human cerebral organoids derived from induced pluripotent stem cells (iPSCs) provide
novel tools for recapitulating the cytoarchitecture of human brain and for studying biological …

Abstract 3D laboratory tissue cultures have emerged as an alternative to traditional 2D
culture systems that do not recapitulate native cell behavior. The discrepancy between in …

The Organ-on-a-Chip (OoC) technology shows great potential to revolutionize the drugs
development pipeline by mimicking the physiological environment and functions of human …

Alzheimer's disease (AD) is a devastating neurodegenerative disorder affecting the aging
population. Despite many studies, there remains an urgent need to identify the root causes …

Region specific brain organoids are brain organoids derived by patterning protocols using
extrinsic signals as opposed to cerebral organoids obtained by self-patterning. The main …

Neurodegenerative diseases are a group of disorders characterized by progressive
degeneration of the structural and functional integrity of the central and peripheral nervous …