Genomic DNA is folded into loops and topologically associating domains (TADs), which
serve important structural and regulatory roles. It has been proposed that these genomic …

The overall success of human reproduction, either spontaneously or after IVF, is highly
dependent upon maternal age. The main reasons for age-related infertility include reduced …

Aneuploidy has been recognized as a hallmark of tumorigenesis for more than 100 years,
but the connection between chromosomal errors and malignant growth has remained …

SMC (structural maintenance of chromosomes) complexes—which include condensin,
cohesin and the SMC5–SMC6 complex—are major components of chromosomes in all …

This review describes the cytokinesis-block micronucleus (CBMN) cytome assay and its
evolution into a molecular cytogenetic method of chromosomal instability (CIN). Micronuclei …

Polyploid cells have genomes that contain multiples of the typical diploid chromosome
number and are found in many different organisms. Studies in a variety of animal and plant …

Urothelial bladder cancer (UBC) is heterogeneous at the clinical, pathological and genetic
levels. Tumor invasiveness (T) and grade (G) are the main factors associated with outcome …

Cohesin is an evolutionarily conserved, four-subunit complex that entraps DNA fibres within
its ring-shaped structure. It was originally identified and named for its role in mediating sister …

The oocyte is the major determinant of embryo developmental competence in women. It
delivers half the chromosomal complement to the embryo, but the maternal and paternal …

Aneuploidy, or an aberrant karyotype, results in developmental disabilities and has been
implicated in tumorigenesis. However, the causes of aneuploidy-induced phenotypes and …