Several different reactive oxygen species (ROS) are generated in vivo. They have roles in
the development of certain human diseases whilst also performing physiological functions …

Abstract The Japanese Clinical Practice Guidelines for Management of Sepsis and Septic
Shock 2020 (J-SSCG 2020), a Japanese-specific set of clinical practice guidelines for sepsis …

Background Studies that have evaluated the use of intravenous vitamin C in adults with
sepsis who were receiving vasopressor therapy in the intensive care unit (ICU) have shown …

Objectives To develop evidence-based recommendations for clinicians caring for children
(including infants, school-aged children, and adolescents) with septic shock and other …

Following the new ESPEN Standard Operating Procedures, the previous guidelines to
provide best medical nutritional therapy to critically ill patients have been updated. These …

A personalized mechanical ventilation approach for patients with adult respiratory distress
syndrome (ARDS) based on lung physiology and morphology, ARDS etiology, lung imaging …

Importance Growing interest in microbial dysbiosis during critical illness has raised
questions about the therapeutic potential of microbiome modification with probiotics. Prior …

Significance: Under homeostatic conditions, the endothelium dynamically regulates vascular
barrier function, coagulation pathways, leukocyte adhesion, and vasomotor tone. During …

Background Many nutrients have powerful immunomodulatory actions with the potential to
alter susceptibility to coronavirus disease 2019 (COVID-19) infection, progression to …

Early oral feeding is the preferred mode of nutrition for surgical patients. Avoidance of any
nutritional therapy bears the risk of underfeeding during the postoperative course after major …