[HTML][HTML] Solid-state NMR spectroscopy in pharmaceutical sciences
Solid-state NMR (ssNMR) spectroscopy analyzes a wide range of pharmaceutical materials
in a non-disruptive and non-invasive manner. The obtained molecular properties at …
in a non-disruptive and non-invasive manner. The obtained molecular properties at …
A systematic and robust assessment of hot-melt extrusion-based amorphous solid dispersions: Theoretical prediction to practical implementation
A Alzahrani, D Nyavanandi, P Mandati… - International Journal of …, 2022 - Elsevier
Amorphous solid dispersions (ASDs) have gained attention as a formulation strategy in
recent years, with the potential to improve the apparent solubility and, hence, the oral …
recent years, with the potential to improve the apparent solubility and, hence, the oral …
Insights into the dissolution mechanism of ritonavir–copovidone amorphous solid dispersions: importance of congruent release for enhanced performance
AS Indulkar, X Lou, GGZ Zhang… - Molecular …, 2019 - ACS Publications
The aim of this study was to probe the dissolution mechanisms of amorphous solid
dispersions (ASDs) of a poorly water-soluble drug formulated with a hydrophilic polymer …
dispersions (ASDs) of a poorly water-soluble drug formulated with a hydrophilic polymer …
Recent strategies in spray drying for the enhanced bioavailability of poorly water-soluble drugs
Poorly water-soluble drugs are a significant and ongoing issue for the pharmaceutical
industry. An overview of recent developments for the preparation of spray-dried delivery …
industry. An overview of recent developments for the preparation of spray-dried delivery …
Selective laser sintering 3-dimensional printing as a single step process to prepare amorphous solid dispersion dosage forms for improved solubility and dissolution …
This study reports the development of ritonavir-copovidone amorphous solid dispersions
(ASDs) and dosage forms thereof using selective laser sintering (SLS) 3-dimensional (3-D) …
(ASDs) and dosage forms thereof using selective laser sintering (SLS) 3-dimensional (3-D) …
Patterns of drug release as a function of drug loading from amorphous solid dispersions: A comparison of five different polymers.
To reduce the pill burden associated with amorphous solid dispersions (ASDs), which arises
from the large quantity of polymer used in the formulation, it is of interest to understand the …
from the large quantity of polymer used in the formulation, it is of interest to understand the …
Role of surfactants in improving release from higher drug loading amorphous solid dispersions
Amorphous solid dispersion formulations (ASD) are increasingly being used as a
formulation strategy to improve bioavailability of poorly soluble drugs. One of the limitations …
formulation strategy to improve bioavailability of poorly soluble drugs. One of the limitations …
Recent advances in understanding the micro-and nanoscale phenomena of amorphous solid dispersions
Many pharmaceutical drugs in the marketplace and discovery pipeline suffer from poor
aqueous solubility, thereby limiting their effectiveness for oral delivery. The use of an …
aqueous solubility, thereby limiting their effectiveness for oral delivery. The use of an …
Using thin film freezing to minimize excipients in inhalable tacrolimus dry powder formulations
We investigated the feasibility of preparing high-potency tacrolimus dry powder for
inhalation using thin film freezing (TFF). We found that using ultra-rapid freezing can …
inhalation using thin film freezing (TFF). We found that using ultra-rapid freezing can …
Understanding the impact of protein–excipient interactions on physical stability of spray-dried protein solids
Mannitol, leucine, and trehalose have been widely used in spray-dried formulations,
especially for inhalation formulations. The individual contribution of these excipients on …
especially for inhalation formulations. The individual contribution of these excipients on …