[HTML][HTML] ALDH1: A potential therapeutic target for cancer stem cells in solid tumors

Y Wei, Y Li, Y Chen, P Liu, S Huang, Y Zhang… - Frontiers in …, 2022 - frontiersin.org
Solid tumors can be divided into benign solid tumors and solid malignant tumors in the
academic community, among which malignant solid tumors are called cancers. Cancer is …

[HTML][HTML] Unlocking the potential of 1, 4-naphthoquinones: A comprehensive review of their anticancer properties

E Angulo-Elizari, A Henriquez-Figuereo… - European Journal of …, 2024 - Elsevier
Cancer encompasses a group of pathologies with common characteristics, high incidence,
and prevalence in all countries. Although there are treatments available for this disease …

[HTML][HTML] Gemcitabine resistance of pancreatic cancer cells is mediated by IGF1R dependent upregulation of CD44 expression and isoform switching

C Chen, S Zhao, X Zhao, L Cao, A Karnad… - Cell Death & …, 2022 - nature.com
Chemoresistance in pancreatic cancer cells may be caused by the expansion of inherently
resistant cancer cells or by the adaptive plasticity of initially sensitive cancer cells. We …

A novel EHD1/CD44/Hippo/SP1 positive feedback loop potentiates stemness and metastasis in lung adenocarcinoma

Y Liu, Y Song, M Cao, W Fan, Y Cui… - Clinical and …, 2022 - Wiley Online Library
Background There is growing evidence that endocytosis plays a pivotal role in cancer
metastasis. In this study, we first identified endocytic and metastasis‐associated genes …

[HTML][HTML] Modulating the Siah2-PHD3-HIF1α axis and/or autophagy potentially retard colon cancer proliferation possibly, due to the damping of colon cancer stem cells

S Zakaria, S Elsebaey, S Allam, A El-Sisi - Biomedicine & Pharmacotherapy, 2022 - Elsevier
Background Hypoxic microenvironment of colon cancer is associated with HIF-1α
upregulation. HIF-1α response elements are responsible for autophagy induction that …

Menadione and protocatechuic acid: A drug combination with antitumor effects in murine osteosarcoma cells

KK Inacio, A de Souza Pessoa, CK Tokuhara… - Archives of Biochemistry …, 2024 - Elsevier
Osteosarcoma (OS) is a primary malignant bone tumor that has an abnormal expression of
oncogenesis and tumor suppressors and causes dysregulation of various signaling …

[HTML][HTML] Characterization of 3D NSCLC Cell Cultures with Fibroblasts or Macrophages for Tumor Microenvironment Studies and Chemotherapy Screening

AMB Garnique, GM Machado-Santelli - Cells, 2023 - mdpi.com
The study of 3D cell culture has increased in recent years as a model that mimics the tumor
microenvironment (TME), which is characterized by exhibiting cellular heterogeneity …

Vitamin K Intake and Risk of Lung Cancer: The Japan Collaborative Cohort Study

F Yan, ES Eshak, A Arafa, A Tamakoshi, H Iso… - Journal of …, 2023 - jstage.jst.go.jp
Background: Limited reports from prospective human studies investigated the possible role
of vitamin K in the development of lung cancer although vitamin K's anticarcinogenic …

Elevation of LEM Domain Containing 1 Predicts Poor Prognosis of NSCLC Patients and Triggers Malignant Stemness and Invasion of NSCLC Cells by Stimulating …

L Li, P Zhang - Current Molecular Medicine, 2024 - ingentaconnect.com
Background: Non-small cell lung cancer (NSCLC) is a leading cause of cancer-related
death globally. LEM domain containing 1 (LEMD1) function has been identified in several …