Alzheimer's disease, one of the most common forms of dementia, is characterized by a slow
progression of cognitive impairment and neuronal loss. Currently, approved treatments for …

In the adult mammalian central nervous system (CNS), axons fail to regenerate
spontaneously after injury because of a combination of extrinsic and intrinsic factors. Despite …

Reconstructing functional neuronal circuits is one major challenge of central nervous system
repair. Through activation of pro-growth signaling pathways, some neurons achieve long …

Progressive and irreversible vision loss in mature and aging adults creates a health and
economic burden, worldwide. Despite the advancements of many contemporary therapies to …

In the injured adult central nervous system (CNS), activation of pro-growth molecular
pathways in neurons leads to long-distance regeneration. However, most regenerative …

Cell replacement therapies may be key in achieving functional recovery in
neurodegenerative optic neuropathies diseases such as glaucoma. One strategy that holds …

Ocular complications of Ebola virus disease are well-documented and long-term sequelae
in survivors are common and lead to considerable morbidity. However, little is currently …

Pathobiology of the intact human retina has been challenging to study due to its relative
inaccessibility and limited sample availability. Thus, there is a great need for new …

The ramified morphology of microglia and the dynamics of their membrane protrusions are
essential for their functions in central nervous system development, homeostasis, and …

It is advantageous to culture the ex vivo retina and other tissues at the air-liquid interface to
allow for more efficient gas exchange. However, gene delivery to these cultures can be …