Simulating non-Markovian stochastic processes

M Boguná, LF Lafuerza, R Toral, MÁ Serrano - Physical Review E, 2014 - APS
We present a simple and general framework to simulate statistically correct realizations of a
system of non-Markovian discrete stochastic processes. We give the exact analytical …

Exact solution of a stochastic protein dynamics model with delayed degradation

LF Lafuerza, R Toral - Physical Review E—Statistical, Nonlinear, and Soft …, 2011 - APS
We study a stochastic model of protein dynamics that explicitly includes delay in the
degradation. We rigorously derive the master equation for the processes and solve it exactly …

Length biases in single-cell RNA sequencing of pre-mRNA

G Gorin, L Pachter - Biophysical Reports, 2023 - cell.com
Single-cell RNA sequencing data can be modeled using Markov chains to yield genome-
wide insights into transcriptional physics. However, quantitative inference with such data …

Assessing markovian and delay models for single-nucleus RNA sequencing

G Gorin, S Yoshida, L Pachter - Bulletin of Mathematical Biology, 2023 - Springer
The serial nature of reactions involved in the RNA life-cycle motivates the incorporation of
delays in models of transcriptional dynamics. The models couple a transcriptional process to …

Noise-and delay-induced regime shifts in an ecological system of vegetation

C Zeng, Q Han, T Yang, H Wang… - Journal of Statistical …, 2013 - iopscience.iop.org
In this paper, the stationary probability distribution (SPD) and mean first passage time
(MFPT) in a vegetation model with time delay are investigated, where the vegetation …

An averaging principle for two-time-scale stochastic functional differential equations

F Wu, G Yin - Journal of Differential Equations, 2020 - Elsevier
Delays are ubiquitous, pervasive, and entrenched in everyday life, thus taking it into
consideration is necessary. Dupire recently developed a functional Itô formula, which has …

Delay chemical master equation: direct and closed-form solutions

A Leier, TT Marquez-Lago - Proceedings of the Royal …, 2015 - royalsocietypublishing.org
The stochastic simulation algorithm (SSA) describes the time evolution of a discrete
nonlinear Markov process. This stochastic process has a probability density function that is …

Exact protein distributions for stochastic models of gene expression using partitioning of Poisson processes

H Pendar, T Platini, RV Kulkarni - … Review E—Statistical, Nonlinear, and Soft …, 2013 - APS
Stochasticity in gene expression gives rise to fluctuations in protein levels across a
population of genetically identical cells. Such fluctuations can lead to phenotypic variation in …

Transient and delay chemical master equations

G Gorin, S Yoshida, L Pachter - bioRxiv, 2022 - biorxiv.org
The serial nature of reactions involved in the RNA life-cycle motivates the incorporation of
delays in models of transcriptional dynamics. The models couple a bursty or switching …

Delay can stabilize: Love affairs dynamics

N Bielczyk, M Bodnar, U Foryś - Applied Mathematics and Computation, 2012 - Elsevier
We discuss two models of interpersonal interactions with delay. The first model is linear, and
allows the presentation of a rigorous mathematical analysis of stability, while the second is …