Oxidative stress: harms and benefits for human health

G Pizzino, N Irrera, M Cucinotta, G Pallio… - Oxidative medicine …, 2017 - Wiley Online Library
Oxidative stress is a phenomenon caused by an imbalance between production and
accumulation of oxygen reactive species (ROS) in cells and tissues and the ability of a …

Valorization of by-products from olive oil industry and added-value applications for innovative functional foods

P Gullon, B Gullon, G Astray, M Carpena… - Food Research …, 2020 - Elsevier
Background In the last years, the consumption of olive oil has experienced a sharp rise due
to its organoleptic and healthy properties and with this the wastes and by-products derived …

Hydroxytyrosol: A natural compound with promising pharmacological activities

M Bertelli, AK Kiani, S Paolacci, E Manara, D Kurti… - Journal of …, 2020 - Elsevier
Hydroxytyrosol is a phenolic phytochemical with antioxidant properties in vitro. It is a natural
compound that can be found in olive leaves and oil. The main dietary source of …

Hydroxytyrosol: Bioavailability, toxicity, and clinical applications

M Robles-Almazan, M Pulido-Moran… - Food Research …, 2018 - Elsevier
Many beneficial properties have been attributed to the Mediterranean diet. Over the years,
researchers have attempted to learn which foods and which food components are …

Beneficial effects of the olive oil phenolic components oleuropein and hydroxytyrosol: focus on protection against cardiovascular and metabolic diseases

S Bulotta, M Celano, SM Lepore, T Montalcini… - Journal of translational …, 2014 - Springer
The overall health beneficial action of olive oil phenolic components is well established.
Recent studies have elucidated the biological effects of two isolated compounds, namely …

Pro-oxidant activity of polyphenols and its implication on cancer chemoprevention and chemotherapy

AJ León-González, C Auger, VB Schini-Kerth - Biochemical pharmacology, 2015 - Elsevier
Reactive oxygen species (ROS) play a major role in carcinogenesis: pro-oxidant agents like
tobacco smoke, asbestos or N-nitrosamines, are known as mutagenic and carcinogenic, and …

Evidence to support the anti-cancer effect of olive leaf extract and future directions

A Boss, KS Bishop, G Marlow, MPG Barnett… - Nutrients, 2016 - mdpi.com
The traditional Mediterranean diet (MD) is associated with long life and lower prevalence of
cardiovascular disease and cancers. The main components of this diet include high intake of …

[HTML][HTML] Efficacy-shaping nanomedicine by loading calcium peroxide into tumor microenvironment-responsive nanoparticles for the antitumor therapy of prostate …

D Wu, ZQ Zhu, HX Tang, ZE Shi, J Kang, Q Liu, J Qi - Theranostics, 2020 - ncbi.nlm.nih.gov
Rationale: Prostate cancer has become one of the most threatening malignant tumors in
men, leading to an imperative need to develop effective and safe therapies. Because of the …

Antitumor perspectives of oleuropein and its metabolite hydroxytyrosol: Recent updates

M Imran, M Nadeem, SA Gilani, S Khan… - Journal of food …, 2018 - Wiley Online Library
Olive fruit is a significant and promising source of potential bioactive compounds such as
oleuropein and hydroxytyrosol. Oleuropein is the ester of elenolic acid and 3, 4 …

[HTML][HTML] The role of autophagy and mitophagy in bone metabolic disorders

S Wang, Z Deng, Y Ma, J Jin, F Qi, S Li… - … journal of biological …, 2020 - ncbi.nlm.nih.gov
Bone metabolic disorders include osteolysis, osteoporosis, osteoarthritis and rheumatoid
arthritis. Osteoblasts and osteoclasts are two major types of cells in bone constituting …