Antibiotics have always been considered one of the wonder discoveries of the 20th century.
This is true, but the real wonder is the rise of antibiotic resistance in hospitals, communities …

Protein synthesis is one of the major targets in the cell for antibiotics. This review endeavors
to provide a comprehensive “post-ribosome structure” A–Z of the huge diversity of antibiotics …

The key role of the bacterial ribosome makes it an important target for antibacterial agents.
Indeed, a large number of clinically useful antibiotics target this complex translational …

The actinobacteria are arguably the richest source of small molecule diversity on the planet.
These compounds have an incredible variety of chemical structures and biological activities …

Understanding how modifications to the ribosome affect function has implications for
studying ribosome biogenesis, building minimal cells, and repurposing ribosomes for …

The increase in antibiotic resistance poses a major threat to global health. Actinomycetes,
the Gram-positive bacteria of the order Actinomycetales, are fertile producers of bioactive …

Functional design of ribosomes with mutant ribosomal RNA (rRNA) can expand
opportunities for understanding molecular translation, building cells from the bottom-up, and …

The ribosome is the cell's factory for protein synthesis. With protein synthesis rates of up to
20 amino acids per second and at an accuracy of 99.99%, the extraordinary catalytic …

Ribosome assembly is a process fundamental for all cellular activities. The efficiency and
accuracy of the subunit assembly are tightly regulated and closely monitored. In the present …

The synthetic capability of the Escherichia coli ribosome has attracted efforts to repurpose it
for novel functions, such as the synthesis of polymers containing non-natural building …