Highlights•Comprehensive TME characterization is required to understand therapy
resistance and sensitivity to current generations of therapeutics•Spatial profiling has …

Ovulation is vital for successful reproduction. Following ovulation, cumulus cells and oocyte
are released, while mural granulosa cells (mGCs) remain sequestered within the post …

In aging, skeletal muscle regeneration declines due to alterations in both myogenic and non-
myogenic cells and their interactions. This regenerative dysfunction is not understood …

During ovulation, the apical wall of the preovulatory follicle breaks down to facilitate gamete
release. In parallel, the residual follicle wall differentiates into a progesterone-producing …

Disruption of the estrous cycle affects fertility and reproductive health. Follicular dynamics
are key to the regularity of the estrous cycle. We identified a novel lincRNA, HEOE, showing …

Yaks (Bos grunniens) exhibit exceptional adaptation to the challenging high-altitude
environment of the Qinghai-Tibetan plateau, making them the sole bovine species capable …

Long noncoding RNAs (lncRNAs), as competitive endogenous RNAs (ceRNAs), can directly
or indirectly affect the proliferation and apoptosis of granulosa cells by regulating microRNA …

The in‐depth mechanisms of microRNA regulation of premature ovarian failure (POF)
remain unclear. Crispr‐cas9 technology was used to construct transgenic mice. The qPCR …

Gonadotropins, including human chorionic gonadotropin (hCG), are used to induce
ovulation, but they have a number of side effects, including ovarian hyperstimulation …

The goat breeding industry on the Tibetan Plateau faces strong selection pressure to
enhance fertility. Consequently, there is an urgent need to develop goat lines with higher …