CLC anion transporters are found in all phyla and form a gene family of eight members in
mammals. Two CLC proteins, each of which completely contains an ion translocation …

The discovery of ClC proteins at the beginning of the 1990s was important for the
development of the Cl-transport research field. ClCs form a large family of proteins that …

ClC-6 is a late endosomal voltage-gated chloride-proton exchanger that is predominantly
expressed in the nervous system. Mutated forms of ClC-6 are associated with severe …

Since the physical process of fluorescence resonance energy transfer (FRET) was
elucidated more than six decades ago, this peculiar fluorescence phenomenon has turned …

After providing a personal description of the convoluted path leading 25 years ago to the
molecular identification of the Torpedo Cl− channel ClC‐0 and the discovery of the CLC …

CLC channels and transporters are expressed in most tissues and fulfill diverse functions.
There are four human CLC channels, ClC-1, ClC-2, ClC-Ka, and ClC-Kb, and five CLC …

The voltage-dependent ClC-1 chloride channel belongs to the CLC channel/transporter
family. It is a homodimer comprising two individual pores which can operate independently …

Temperature-sensitive transient receptor potential (TRP) ion channels are members of the
large tetrameric cation channels superfamily but are considered to be uniquely sensitive to …

Membrane proteins mediate a number of cellular functions and are associated with several
diseases and also play a crucial role in pathogenicity. Due to their importance in cellular …

In 1970, the study of the pathomechanisms underlying myotonia in muscle fibers isolated
from myotonic goats highlighted the importance of chloride conductance for skeletal muscle …