Selenium (Se) is a nutritional trace mineral essential for various aspects of human health
that exerts its effects mainly through its incorporation into selenoproteins as the amino acid …

Selenoproteins are proteins containing selenium in the form of the 21st amino acid,
selenocysteine. Members of this protein family have many diverse functions, but their …

Congenital muscular dystrophies (CMDs) are early onset disorders of muscle with
histological features suggesting a dystrophic process. The congenital muscular dystrophies …

The human selenoprotein family contains 25 members that share the common feature of
containing the amino acid, selenocysteine (Sec). Seven selenoproteins are localized to the …

The expression of selenoproteins is controlled on each one of the textbook steps of protein
biosynthesis, ie, during gene transcription, RNA processing, translation and …

Dietary selenium (Se) deficiency causes muscular dystrophy in various species, but the
molecular mechanism remains unclear. Our objectives were to investigate: 1) if dietary Se …

Selenium is a fascinating element that has a long history, most of which documents it as a
deleterious element to health. In more recent years, selenium has been found to be an …

Significance: Selenium is an essential trace element that is incorporated in the small but vital
family of proteins, namely the selenoproteins, as the selenocysteine amino acid residue. In …

Healthy cells continually produce low levels of reactive oxygen species (ROS), which are
buffered by multiple antioxidant systems. Imbalance between ROS production and …

BACKGROUND: The amino acid selenocysteine (Sec) is the major biological form of the
trace element selenium. Sec is co-translationally incorporated in selenoproteins. There are …