Lipid droplets are dynamic organelles that store neutral lipids, serve the metabolic needs of
cells, and sequester lipids to prevent lipotoxicity and membrane damage. Here we review …

Perilipins are abundant lipid droplet (LD) proteins present in all metazoans and also in
Amoebozoa and fungi. Humans express five perilipins, which share a similar domain …

Contact sites between lipid droplets and other organelles are essential for cellular lipid and
energy homeostasis upon metabolic demands. Detection of these contact sites at the …

Lipid droplets (LDs), once considered mere storage depots for lipids, have gained
recognition for their intricate roles in cellular processes, including metabolism, membrane …

Membrane contact sites (MCSs) are sites of close apposition between two organelles used
to exchange ions, lipids, and information. Cells respond to changing environmental or …

Oxidative stress is the imbalance between the production of reactive oxygen species (ROS)
and antioxidants in a cell. In the heart, oxidative stress may deteriorate calcium handling …

Lipid droplets (LDs) are dynamic storage organelles with central roles in lipid and energy
metabolism. They consist of a core of neutral lipids, such as triacylglycerol, which is …

Electron microscopy (EM), in its various flavors, has significantly contributed to our
understanding of lipid droplets (LD) as central organelles in cellular metabolism. For …

Our body stores energy mostly in form of fatty acids (FAs) in lipid droplets (LDs). From there
the FAs can be mobilized and transferred to peroxisomes and mitochondria. This transfer is …

Lipid droplet tethering with mitochondria for fatty acid oxidation is critical for tumor cells to
counteract energy stress. However, the underlying mechanism remains unclear. Here, we …