Mammalian skeletal muscle shows an enormous variability in its functional features such as
rate of force production, resistance to fatigue, and energy metabolism, with a wide spectrum …

Limb-girdle muscular dystrophies (LGMD) are a highly heterogeneous group of muscle
disorders, which first affect the voluntary muscles of the hip and shoulder areas. The …

We present a DNA library preparation method that has allowed us to reconstruct a high-
coverage (30×) genome sequence of a Denisovan, an extinct relative of Neandertals. The …

Mutations in the Proteolytic Enzyme Calpain 3 Cause Limb-Girdle Muscular Dystrophy Type
2A Page 1 Cell, Vol. 81, 27-40, April 7, 1995, Copyright © 1995 by Cell Press Mutations in …

Muscle–eye–brain disease (MEB) and Fukuyama congenital muscular dystrophy (FCMD)
are congenital muscular dystrophies with associated, similar brain malformations,. The …

The muscular dystrophies are a group of heterogeneous genetic diseases characterized by
progressive degeneration and weakness of skeletal muscle. Since the discovery of the first …

Muscular dystrophies are a group of diseases that primarily affect skeletal muscle and are
characterized by progressive muscle wasting and weakness. Although these diseases have …

The dystrophin–glycoprotein complex (DGC) is a multisubunit complex that connects the
cytoskeleton of a muscle fiber to its surrounding extracellular matrix. Mutations in the DGC …

To gain insight into the regeneration deficit of MyoD−/− muscle, we investigated the growth
and differentiation of cultured MyoD−/− myogenic cells. Primary MyoD−/− myogenic cells …

The term muscular dystrophy covers a diverse group of inherited disorders characterized by
progressive muscle weakness and wasting in which the primary defect becomes …