The characteristic molecular composition of the different glycosaminoglycans (GAGs) is
related to their role as structural components and regulators of a multitude of functions of …

Orthobiologics continue to gain popularity in many areas of medical science, especially in
the field of regenerative medicine. Platelet-rich plasma derivatives are orthobiologic tools of …

Activation of the cyclic guanosine monophosphate (GMP)-AMP (cGAMP) sensor STING
requires its translocation from the endoplasmic reticulum to the Golgi apparatus and …

Amyloids are highly organized cross–β-sheet–rich protein or peptide aggregates that are
associated with pathological conditions including Alzheimer's disease and type II diabetes …

This chapter focuses on the structure, biosynthesis, and general biology of proteoglycans.
Topics include a description of the major families of proteoglycans, their characteristic …

Proteoglycans (PGs) are glycosylated proteins of biological importance at cell surfaces, in
the extracellular matrix, and in the circulation. PGs are produced and modified by …

Proteoglycans are key components of extracellular matrices, providing structural support as
well as influencing cellular behaviour in physiological and pathological processes. The …

To address the biological function of the scarcely studied intracellular proteoglycans, we
targeted the gene for serglycin (SG), the only known committed intracellular proteoglycan …

Serglycin has been initially characterized as an intracellular proteoglycan expressed by
hematopoietic cells. All inflammatory cells highly synthesize serglycin and store it in …

Mast cells are protective against snake venom sarafotoxins that belong to the endothelin
(ET) peptide family. The molecular mechanism underlying this recently recognized innate …