Cyclin dependent kinase 1 (CDK1) has been primarily identified as a key cell cycle regulator
in both mitosis and meiosis. Recently, an extramitotic function of CDK1 emerged when …

Oocyte meiotic maturation is a vital and final process in oogenesis. Unlike somatic cells, the
oocyte needs to undergo two continuous meiotic divisions (meiosis I and meiosis II) to …

Sex chromosomes in males of most eutherian mammals share only a small homologous
segment, the pseudoautosomal region (PAR), in which the formation of double-strand …

Vertebrate oocytes face a particular challenge concerning the regulation of gene expression
during meiotic maturation. Global transcription becomes quiescent in fully grown oocytes …

During oogenesis, oocytes arrest at meiotic prophase I to acquire competencies for
resuming meiosis, fertilization, and early embryonic development. Following this arrested …

Cyclins and cyclin-dependent kinases (CDKs) are key regulators of the cell cycle. Most of
our understanding of their functions has been obtained from studies in single-cell organisms …

Meiosis with a single round of DNA replication and two successive rounds of chromosome
segregation requires specific cyclins associated with cyclin-dependent kinases (CDKs) to …

Cyclins associate with cyclin-dependent serine/threonine kinase 1 (CDK1) to generate the M
phase-promoting factor (MPF) activity essential for progression through mitosis and meiosis …

Chromosome segregation is driven by separase, activity of which is inhibited by binding to
securin and cyclin B1/CDK1. In meiosis, premature separase activity will induce aneuploidy …

Bisphenol A (BPA) is an established environmental endocrine disruptor and can interfere
with the development of female germ cells. However, the underlying mechanisms are still …