Complement evasion strategies of viruses: an overview
Being a major first line of immune defense, the complement system keeps a constant vigil
against viruses. Its ability to recognize large panoply of viruses and virus-infected cells, and …
against viruses. Its ability to recognize large panoply of viruses and virus-infected cells, and …
The imitation game: a viral strategy to subvert the complement system
Viruses are obligate parasites of cellular hosts and therefore are constantly confronted with
the host immune system. Evasion of innate immunity mechanisms by viruses is paramount …
the host immune system. Evasion of innate immunity mechanisms by viruses is paramount …
Spatially conserved motifs in complement control protein domains determine functionality in regulators of complement activation-family proteins
H Ojha, P Ghosh, H Singh Panwar, R Shende… - Communications …, 2019 - nature.com
Regulation of complement activation in the host cells is mediated primarily by the regulators
of complement activation (RCA) family proteins that are formed by tandemly repeating …
of complement activation (RCA) family proteins that are formed by tandemly repeating …
The modulation of apoptotic pathways by gammaherpesviruses
Apoptosis or programmed cell death is a tightly regulated process fundamental for cellular
development and elimination of damaged or infected cells during the maintenance of …
development and elimination of damaged or infected cells during the maintenance of …
Viral regulators of complement activation: structure, function and evolution
The complement system surveillance in the host is effective in controlling viral propagation.
Consequently, to subvert this effector mechanism, viruses have developed a series of …
Consequently, to subvert this effector mechanism, viruses have developed a series of …
AGI-134: a fully synthetic α-Gal glycolipid that converts tumors into in situ autologous vaccines, induces anti-tumor immunity and is synergistic with an anti-PD-1 …
SM Shaw, J Middleton, K Wigglesworth… - Cancer Cell …, 2019 - Springer
Background Treatments that generate T cell-mediated immunity to a patient's unique
neoantigens are the current holy grail of cancer immunotherapy. In particular, treatments that …
neoantigens are the current holy grail of cancer immunotherapy. In particular, treatments that …
Virus-encoded complement regulators: current status
Viruses require a host for replication and survival and hence are subjected to host
immunological pressures. The complement system, a crucial first response of the host …
immunological pressures. The complement system, a crucial first response of the host …
Cathepsin K regulates localization and secretion of Tartrate-Resistant Acid Phosphatase (TRAP) in TRAP-overexpressing MDA-MB-231 breast cancer cells
A Reithmeier, M Norgård, B Ek-Rylander… - BMC Molecular and Cell …, 2020 - Springer
Background Tartrate–resistant acid phosphatase (TRAP/ACP5) belongs to the binuclear
metallophosphatase family and is present in two isoforms. The primary translation product is …
metallophosphatase family and is present in two isoforms. The primary translation product is …
Mutational analysis of Kaposica reveals that bridging of MG2 and CUB domains of target protein is crucial for the cofactor activity of RCA proteins
The complement system has evolved to annul pathogens, but its improper regulation is
linked with diseases. Efficient regulation of the system is primarily provided by a family of …
linked with diseases. Efficient regulation of the system is primarily provided by a family of …
Viral-derived complement inhibitors: current status and potential role in immunomodulation
H Abou-El-Hassan, H Zaraket - Experimental Biology and …, 2017 - journals.sagepub.com
The complement system is one of the body's major innate immune defense mechanisms in
vertebrates. Its function is to detect foreign bodies and promote their elimination through …
vertebrates. Its function is to detect foreign bodies and promote their elimination through …