Heparan sulfate (HS) proteoglycans are extended (-GlcAβ1, 4GlcNAcα1, 4-) n co-polymers
containing decorations of sulfation and epimerization that are linked to cell surface and …

Heparan sulfates are complex polysaccharides that mediate the interaction with a broad
range of protein ligands at the cell surface. A key step in heparan sulfate biosynthesis is …

The management of children with syndromes associated with an increased risk of benign
and malignant neoplasms is a complex challenge for health care professionals. The 2023 …

The epithelial–mesenchymal transition (EMT) program is crucial for transforming carcinoma
cells into a partially mesenchymal state, enhancing their chemoresistance, migration, and …

Chondrosarcoma (CS) is the second most common primary bone malignancy, known for its
unique transcriptional landscape that renders most CS subtypes resistant to chemotherapy …

Simple Summary Some locally advanced pelvic bone tumors are deemed unresectable and,
as such, not suitable for curative surgery. In this setting, treatment options are generally …

Hereditary multiple exostoses (HME) is an autosomal dominant skeletal disorder primarily
linked with mutations in Exostosin-1 (EXT1) and Exostosin-2 (EXT2) genes. However, not all …

Abstract Background Liquid biopsy and Integrative Genomic Profiling (IGP) are yet to be
implemented into routine Radiation Oncology. Here we assess the utility of germline, tumour …

Background Hereditary multiple exostoses (HME) is an autosomal dominant skeletal
disorder characterized by the development of multiple, circumscript and usually symmetric …

Multiple Osteochondromatosis (MO, MIM 133700 & 133701), an autosomal dominant O-
glycosylation disorder (EXT1/EXT2-CDG), can be associated with a reduction in skeletal …