Neurodegenerative disorders, including Alzheimer's disease, Parkinson's disease and
Huntington's disease, present a major health issue and financial burden for health care …

Alzheimer's disease (AD) is one of the most common neurodegenerative disorders in elderly
people. Considering the multifactorial nature of AD, the concept of multi-target-directed …

Diseases of infection, of neurodegeneration (such as Alzheimer's and Parkinson's
diseases), and of malignancy (cancers) have complex and varied causative factors. Modern …

No drug has been approved to prevent neuronal cell loss in patients suffering from
Parkinson's disease (PD) or Alzheimer's disease (AD); despite increased comprehension of …

The use of an acetylene (ethynyl) group in medicinal chemistry coincides with the launch of
the Journal of Medicinal Chemistry in 1959. Since then, the acetylene group has been …

Alzheimer's disease is a multifactorial and fatal neurodegenerative disorder characterized
by decline of cholinergic function, deregulation of other neurotransmitter systems, β-amyloid …

Heavy metals are reported as neurodegenerative disorders progenitor. They play a role in
the precipitation of abnormal β-amyloid protein and hyper-phosphorylated tau, the main …

HIGHLIGHTS ASS234 is a MTDL compound containing a moiety from Donepezil and the
propargyl group from the PF 9601N, a potent and selective MAO B inhibitor. This compound …

The present article reviews published efforts to study acetylcholinesterase and
butyrylcholinesterase structure and function using computer-based modeling and simulation …

Alzheimer's Disease (AD) is a progressive neurodegenerative disorder that effects 50 million
people worldwide. In this review, AD pathology and the development of novel therapeutic …