Single-molecule force spectroscopy is a unique method that can probe the structural
changes of single proteins at a high spatiotemporal resolution while mechanically …

Membrane proteins exist within the highly hydrophobic membranes surrounding cells and
organelles, playing key roles in cellular function. It is becoming increasingly clear that the …

The flexible regions represented by loops have been the focus of protein stability
engineering. However, residues located in specific rigid regions are also crucial for protein …

Cellular function is underlined by megadalton assemblies organizing in proximity, forming
communities. Metabolons are protein communities involving metabolic pathways such as …

By converting physical forces into electrical signals or triggering intracellular cascades,
stretch-activated ion channels allow the cell to respond to osmotic and mechanical stress …

Cavities are created by hydrophobic interactions between residue side chain atoms during
the folding of enzymes. Redesigning cavities can improve the thermostability and catalytic …

Protein folding is a fundamental process of life with important implications throughout
biology. Indeed, tens of thousands of mutations have been associated with diseases, and …

After decades of progress in computational protein design, the design of proteins folding and
functioning in lipid membranes appears today as the next frontier. Some notable successes …

Most enzyme modification strategies focus on designing the active sites or their surrounding
structures. Interestingly, a large portion of the enzymes (60%) feature active sites located …

L-Theanine is a multifunctional nonprotein amino acid found naturally in tea leaves. It has
been developed as a commercial product for a wide range of applications in the food …