Interstitial lung disease (ILD) is an increasingly recognized complication of rheumatoid
arthritis (RA) and is associated with significant morbidity and mortality. In addition …

The Pathogenesis of Rheumatoid Arthritis | New England Journal of Medicine Skip to main
content The New England Journal of Medicine homepage Advanced Search SEARCH …

A key unanswered question in the pathophysiology of rheumatoid arthritis (RA) is how
systemic autoimmunity progresses to joint-specific inflammation. In patients with seropositive …

Rheumatoid arthritis (RA) is strongly associated with the human leukocyte antigen (HLA)-
DRB1 locus that possesses the shared susceptibility epitope (SE) and the citrullination of …

Extra-articular Manifestations in Rheumatoid Arthritis - PMC Back to Top Skip to main
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Objectives: A gene–environment interaction between HLA-DR shared epitope genes and
smoking in anti-cyclic citrullinated peptide antibody-positive rheumatoid arthritis (RA) has …

Interstitial lung disease (ILD) is a frequent extraarticular manifestation of rheumatoid arthritis
(RA). While the nonspecific interstitial pneumonia pattern predominates in most forms of …

Antibodies to citrullinated proteins (ACPA), ie, to peptides posttranslationally modified by the
conversion of arginine to citrulline, are specific serological markers for rheumatoid arthritis …

Interstitial lung disease (ILD) accounts for the major cause of morbidity and mortality in
rheumatoid arthritis (RA). However, little is known of the pathogenesis, diagnosis and …

Objective Autoantibodies to citrullinated proteins (ACPAs) are specific for rheumatoid
arthritis (RA) and probably are involved in its pathophysiology. Citrullyl residues …