Methylation of cytosines in the mammalian genome represents a key epigenetic modification
and is dynamically regulated during development. Compelling evidence now suggests that …

DNA methylation provides a pivotal layer of epigenetic regulation in eukaryotes that has
significant involvement for numerous biological processes in health and disease. The …

Solid-state nanopores are nm sized apertures formed in thin synthetic membranes. These
single molecule sensors have been used in a variety of biophysical and diagnostic …

Much more than ever, nucleic acids are recognized as key building blocks in many of lifeʼs
processes, and the science of studying these molecular wonders at the single-molecule …

Just over 2 years ago, TET1 was found to catalyse the oxidation of 5-methylcytosine, a well-
known epigenetic mark, into 5-hydroxymethylcytosine in mammalian DNA. The exciting …

5-Methylcytosine can be converted to 5-hydroxymethylcytosine (5hmC) in mammalian DNA
by the ten-eleven translocation (TET) enzymes. We introduce oxidative bisulfite sequencing …

Emerging single-cell epigenomic methods are being developed with the exciting potential to
transform our knowledge of gene regulation. Here we review available techniques and …

Provided herein are methods and devices for characterizing a biomolecule parameter by a
nanopore-containing mem brane, and also methods for making devices that can be used in …

Recent studies have found methyl-6-adenosine in thousands of mammalian genes, and this
modification is most pronounced near the beginning of the 3'UTR. We present a perspective …

Precise and efficient mapping of epigenetic markers on DNA may become an important
clinical tool for prediction and identification of ailments. Methylated CpG sites are involved in …