Recent progress of bioanalytical techniques has accelerated the deep understanding of
cellular states and development of novel drugs as well as medical diagnosis. Particularly …

Since diabetes is becoming a global epidemic, there is a great need to develop early β-cell
specific diagnostic techniques for this disorder. There are two types of diabetes (ie, type 1 …

To prevent infections associated with medical implants, various antimicrobial silver-coated
implant materials have been developed. However, these materials do not always provide …

Osteomyelitis remains a serious problem in the orthopedic field. There are only a few animal
models in which the quantity and distribution of bacteria can be reproducibly traced. Here …

Whether Propionibacterium acnes (P. acnes) causes surgical-site infections (SSI) after
orthopedic surgery is controversial. We previously reported that we frequently find P. acnes …

Diabetes mellitus is a growing worldwide epidemic disease, currently affecting 1 in 12
adults. Treatment of disease complications typically consumes∼ 10% of healthcare budgets …

Abstract Purpose of Review To discuss advances in our understanding of beta-cell
heterogeneity and the ramifications of this for type 1 diabetes (T1D) and its therapy. Recent …

The pancreatic beta cell is a highly specialized cell type whose primary function is to secrete
insulin in response to nutrients to maintain glucose homeostasis in the body. As such, the …

A hallmark of diabetes mellitus is the inability of pancreatic β-cells to secrete sufficient
amounts of insulin for maintaining normoglycemia. The formation of smaller islets may …

We generated a mouse model (MIP-Luc-VU-NOD) that enables non-invasive
bioluminescence imaging (BLI) of beta cell loss during the progression of autoimmune …