Bone vasculature and bone marrow vascular niches in health and disease

J Chen, M Hendriks, A Chatzis… - Journal of Bone and …, 2020 - academic.oup.com
Bone vasculature and bone marrow vascular niches supply oxygen, nutrients, and secrete
angiocrine factors required for the survival, maintenance, and self‐renewal of stem and …

The role of osteoprotegerin in the crosstalk between vessels and bone: Its potential utility as a marker of cardiometabolic diseases

L Rochette, A Meloux, E Rigal, M Zeller, Y Cottin… - Pharmacology & …, 2018 - Elsevier
Among the numerous molecules that are being studied for their potential utility as
biomarkers of cardiovascular diseases, much interest has been shown in the superfamily of …

Skeleton-vasculature chain reaction: a novel insight into the mystery of homeostasis

M Chen, Y Li, X Huang, Y Gu, S Li, P Yin, L Zhang… - Bone Research, 2021 - nature.com
Angiogenesis and osteogenesis are coupled. However, the cellular and molecular
regulation of these processes remains to be further investigated. Both tissues have recently …

The cellular mechanobiology of aging: from biology to mechanics

A Bajpai, R Li, W Chen - Annals of the New York Academy of …, 2021 - Wiley Online Library
Aging is a chronic, complicated process that leads to degenerative physical and biological
changes in living organisms. Aging is associated with permanent, gradual physiological …

Role of angiocrine signals in bone development, homeostasis and disease

U Sivan, J De Angelis, AP Kusumbe - Open Biology, 2019 - royalsocietypublishing.org
Skeletal vasculature plays a central role in the maintenance of microenvironments for
osteogenesis and haematopoiesis. In addition to supplying oxygen and nutrients …

[HTML][HTML] Osteoclast-derived apoptotic bodies show extended biological effects of parental cell in promoting bone defect healing

Q Ma, M Liang, N Limjunyawong, Y Dan, J Xing, J Li… - Theranostics, 2020 - ncbi.nlm.nih.gov
Apoptotic bodies (ABs) traditionally considered as garbage bags that enclose residual
components of dead cells are gaining increasing attentions due to their potential roles in …

A comparison of osteoblast and osteoclast in vitro co-culture models and their translation for preclinical drug testing applications

A Sieberath, E Della Bella, AM Ferreira… - International journal of …, 2020 - mdpi.com
As the population of western societies on average ages, the number of people affected by
bone remodeling-associated diseases such as osteoporosis continues to increase. The …

A complex role for lipocalin 2 in bone metabolism: global ablation in mice induces osteopenia caused by an altered energy metabolism

M Capulli, M Ponzetti, A Maurizi… - Journal of Bone and …, 2018 - academic.oup.com
ABSTRACT Lipocalin 2 (Lcn2) is an adipokine that carries out a variety of functions in
diverse organs. We investigated the bone phenotype and the energy metabolism of Lcn2 …

Changes in human foetal osteoblasts exposed to the random positioning machine and bone construct tissue engineering

V Mann, D Grimm, TJ Corydon, M Krüger… - International Journal of …, 2019 - mdpi.com
Human cells, when exposed to both real and simulated microgravity (s-µ g), form 3D tissue
constructs mirroring in vivo architectures (eg, cartilage, intima constructs, cancer spheroids …

New Insights to the Crosstalk between Vascular and Bone Tissue in Chronic Kidney Disease–Mineral and Bone Disorder

ML Mace, S Egstrand, M Morevati, K Olgaard, E Lewin - Metabolites, 2021 - mdpi.com
Vasculature plays a key role in bone development and the maintenance of bone tissue
throughout life. The two organ systems are not only linked in normal physiology, but also in …