Interactions between the immune and nervous systems are of central importance in
neuropathic pain, a common and debilitating form of chronic pain caused by a lesion or …

A peripheral injury drives neuroimmune interactions at the level of the injury and throughout
the neuraxis. Understanding these systems will be beneficial in the pursuit to target …

Resident macrophages are distributed across all tissues and are highly heterogeneous due
to adaptation to different tissue-specific environments. The resident macrophages of the …

The impact of the gut microbiota on glial cell growth and maturation via the gut-brain axis is
highlighted herein. Considering that glial activation is crucial for onset and maintenance of …

Mounting evidence shows sex-related differences in the experience of pain with women
suffering more from chronic pain than men. Yet, our understanding of the biological basis …

Immune cells play a critical role in promoting neuroinflammation and the development of
neuropathic pain. However, some subsets of immune cells are essential for pain resolution …

Given that the incidence of cancer is dramatically increasing nowadays, cancer-related
neuropathic pain including tumor-related and therapy-related pain gradually attracts more …

Pain is estimated to affect more than 20% of the global population, imposing incalculable
health and economic burdens. Effective pain management is crucial for individuals suffering …

Neuropathic pain is a common type of chronic pain, primarily caused by peripheral nerve
injury. Different T-cell subtypes play various roles in neuropathic pain caused by peripheral …

Neurological pain (NP) is always accompanied by symptoms of depression, which seriously
affects physical and mental health. In this study, we identified the common hub genes (Co …